Type

Journal Article

Authors

Lorraine Brennan
Jim Kaput
Michael J Gibney
Wim H Saris
Miriam F Ryan
Arne Astrup
Helen M Roche
Susan L Coort
Chris T Evelo
Marie-Pier Scott-Boyer
and 4 others

Subjects

Psychology

Topics
decision making fat mass age female clinical utility protein drivers diagnostic tests male phenotype proteomics mass fat pathway sex biomarker sexual

Sexual dimorphism, age, and fat mass are key phenotypic drivers of proteomic signatures (2017)

Abstract Validated protein biomarkers are needed for assessing health trajectories, predicting and subclassifying disease, and optimizing diagnostic and therapeutic clinical decision-making. The sensitivity, specificity, accuracy, and precision of single or combinations of protein biomarkers may be altered by differences in physiological states limiting the ability to translate research results to clinically useful diagnostic tests. Aptamer based affinity assays were used to test whether low abundant serum proteins differed based on age, sex, and fat mass in a healthy population of 94 males and 102 females from the MECHE cohort. The findings were replicated in 217 healthy male and 377 healthy female participants in the DiOGenes consortium. Of the 1129 proteins in the panel, 141, 51, and 112 proteins (adjusted p < 0.1) were identified in the MECHE cohort and significantly replicated in DiOGenes for sexual dimorphism, age, and fat mass, respectively. Pathway analysis classified a subset of proteins from the 3 phenotypes to the complement and coagulation cascades pathways and to immune and coagulation processes. These results demonstrated that specific proteins were statistically associated with dichotomous (male vs female) and continuous phenotypes (age, fat mass), which may influence the identification and use of biomarkers of clinical utility for health diagnosis and therapeutic strategies.
Collections Ireland -> University College Dublin -> Conway Institute Research Collection
Ireland -> University College Dublin -> Conway Institute
Ireland -> University College Dublin -> Public Health, Physiotherapy and Sports Science Research Collection
Ireland -> University College Dublin -> Agriculture and Food Science Research Collection

Full list of authors on original publication

Lorraine Brennan, Jim Kaput, Michael J Gibney, Wim H Saris, Miriam F Ryan, Arne Astrup, Helen M Roche, Susan L Coort, Chris T Evelo, Marie-Pier Scott-Boyer and 4 others

Experts in our system

1
Lorraine Brennan
University College Dublin
Total Publications: 166
 
2
Michael J Gibney
University College Dublin
Total Publications: 102
 
3
Wim H M Saris
University College Dublin
Total Publications: 39
 
4
Miriam Ryan
University College Dublin
Total Publications: 34
 
5
Helen M. Roche
University College Dublin
Total Publications: 105