Type

Journal Article

Authors

Eoin P Cummins
Padraic G. (Padraic Gerard) Fallon
Glen Doherty
Cormac T Taylor

Subjects

Microbiology

Topics
transcription factors nf kb network biology immune cells hif hypoxia dependent regulations hypoxic sensitivity immune pathways

Hypoxia-dependent regulation of inflammatory pathways in immune cells (2016)

Abstract Uncontrolled inflammation underpins a diverse range of diseases where effective therapy remains an unmet clinical need. Hypoxia is a prominent feature of the inflammatory microenvironment that regulates key transcription factors including HIF and NF-κB in both innate and adaptive immune cells. In turn, altered activity of the pathways controlled by these factors can affect the course of inflammation through the regulation of immune cell development and function. In this review, we will discuss these pathways and the oxygen sensors that confer hypoxic sensitivity in immune cells. Furthermore, we will describe how hypoxia-dependent pathways contribute to immunity and discuss their potential as therapeutic targets in inflammatory and infectious disease.
Collections Ireland -> University College Dublin -> Conway Institute Research Collection
Ireland -> University College Dublin -> SBI Research Collection
Ireland -> University College Dublin -> Conway Institute
Ireland -> University College Dublin -> Medicine Research Collection

Full list of authors on original publication

Eoin P Cummins, Padraic G. (Padraic Gerard) Fallon, Glen Doherty, Cormac T Taylor

Experts in our system

1
Eoin P. Cummins
University College Dublin
Total Publications: 53
 
2
Padraic Fallon
Trinity College Dublin
Total Publications: 154
 
3
Glen A Doherty
University College Dublin
Total Publications: 57
 
4
Cormac T. Taylor
University College Dublin
Total Publications: 110