Type

Conference Proceedings

Authors

Jens Ducree
Richard O'Kennedy
Julia Zapatero
Seán Fitzgerald
Hui Ma
Elaine Andrade
Ciaran Rogers
Alexander Garvey
Matthew Agnew
Glen Reilly
and 1 others

Subjects

Chemistry

Topics
biotechnology cardiovascular disease biomedical engineering analytical chemistry microfluidics biosensors mpo poc detection sample to answer fabp

Laser-actuated centrifugo-pneumatic flow control towards ‘sample-to-answer’ integrated detection of multi-marker panels at the point-of-care (2018)

Abstract Point-of-care diagnostics devices require user friendly automation of multi-step / multi-reagent bioanalytical protocols. We demonstrate, for the first time, Laser-actuated, Centrifugo-Pneumatic Valves (LCPVs) which open on-demand by ablating a remotely connected polymeric membrane with an instrument-based laser. Due to its small footprint, isolation of radiation-induced heating from the biological fluids and independence of radial position & contact-angle, the novel LCPV technology enables large–scale integration of flexibly customizable and operationally robust centrifugal microfluidic “Lab-on-a-Disc” (LoaD) systems. As a pilot application, we demonstrate the detection of Fatty Acid Binding Protein and Myeloperoxidase, both potential biomarkers used for cardiovascular disease (CVD) determination.
Collections Ireland -> Dublin City University -> Publication Type = Conference or Workshop Item
Ireland -> Dublin City University -> Subject = Physical Sciences: Analytical chemistry
Ireland -> Dublin City University -> Subject = Biological Sciences: Microfluidics
Ireland -> Dublin City University -> Subject = Biological Sciences: Biotechnology
Ireland -> Dublin City University -> Status = In Press
Ireland -> Dublin City University -> DCU Faculties and Centres = DCU Faculties and Schools: Faculty of Science and Health: School of Physical Sciences
Ireland -> Dublin City University -> DCU Faculties and Centres = DCU Faculties and Schools: Faculty of Science and Health: School of Biotechnology
Ireland -> Dublin City University -> Subject = Engineering: Biomedical engineering
Ireland -> Dublin City University -> Subject = Biological Sciences: Biosensors

Full list of authors on original publication

Jens Ducree, Richard O'Kennedy, Julia Zapatero, Seán Fitzgerald, Hui Ma, Elaine Andrade, Ciaran Rogers, Alexander Garvey, Matthew Agnew, Glen Reilly and 1 others

Experts in our system

1
Jens Ducree
Dublin City University
Total Publications: 83
 
2
R O'Kennedy
Dublin City University
Total Publications: 197
 
3
Seán Fitzgerald
Dublin City University
Total Publications: 5
 
4
Hui Ma
Dublin City University
Total Publications: 3