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animals drug effects pharmacology humans metabolism physiology male rats female physiopathology drug therapy rats, wistar therapeutic use blood antagonists & inhibitors administration & dosage chemistry analogs & derivatives adult pathology adverse effects rats, sprague-dawley mice this review blood pressure dose-response relationship, drug nitric oxide middle aged enzymology prevention & control cytology muscle contraction aged Muscle, Skeletal chemically induced etiology time factors biosynthesis pharmacokinetics brain therapy cells, cultured ph.d. trinity college dublin genetics toxicity enzyme inhibitors disease models, animal cattle calcium signal transduction cell line electric stimulation Endothelium, Vascular innervation nitric oxide synthase hypertension inflammation complications kinetics anti-inflammatory blood supply colon hippocampus mice, inbred c57bl drug delivery oxidative stress apoptosis cancer drug delivery systems heart rate platelet aggregation medicine and health sciences pregnancy Muscle, Smooth, Vascular drug interactions